Endocrine Abstracts

Aim: To evaluate clinical presentation and thyroid dysfunction types in children with thyromegaly.Patients and methods: Thirty-nine children were referred to endocrinologist examination because of thyromegaly. Assessment of clinical history, physical examination, auxological data pubertal staging and complete evaluation of basal thyroid function were carried out in all children. Thyroid autoantibodies, urinary iodine excretion (UIE) and ultrasound examin...

Introduction: Growth response in GH deficient children during GH replacement therapy rarely fulfil our projections and patient’s expectations. We here report three cases with outstanding growth response.Case reports: First patient was diagnosed as gluten enteropathy in early childhood, but the diet didn’t improve his growth. At age of 7 years the diagnosis of isolated GH deficiency (GHD) was established and GH substitution therapy introduced. N...

Background: The most striking change in diabetes over recent years has been the convergence of previously distinctive phenotypes. Recently diagnosed children are younger, taller and with greater BM. Pediatric endocrinologists are facing with children presenting mixed signs of both diabetes types. So called hybrid diabetes, or type 1½ has insulin resistance in type 1 phenotype and vice versa autoimmunity in obese children.Patients and methods: Ten ch...

Hyperprolactinaemia is the most common disturbance in the pituitary gland function. Different physiological and patological conditions could influnce prolactin (PRL) secretion. Prolactin secreting tumors (micro and macroprolactinomas) are rare in children and adolescents (estimated incidence is 1 per milion). Functional diversity of prolactin action is responsable for different initial clinical expression of hyperprolactinaemia.We investigated causes of ...